Mexican Chicken Casserole

Looking for a quick and delicious weeknight dinner? This Mexican Chicken Casserole is loaded with shredded chicken, gooey cheese, black beans, corn, and bold Tex-Mex spices, all baked to perfection. It’s a one-pan, crowd-pleasing recipe that’s perfect for busy nights or meal prepping. Whether you serve it with additional tortilla chips, over rice, or wrapped in warm tortillas, this cheesy chicken casserole delivers comfort food with a zesty kick. Try this easy, family-friendly Mexican-inspired dinner tonight!

Ingredients to Make Mexican Chicken Casserole Recipe

This Easy Mexican Chicken Casserole is a flavor-packed family favorite! Ingredients you’ll need to make the best Mexican Chicken Casserole: (Scroll down for the full printable recipe card.)

Chicken – Fully cooked and shredded rotisserie chicken or any cooked chicken.
Corn – Whole kernel corn adds a hint of sweetness to balance the spice.
Beans – Black beans add bulk.
Soup – One can cream of chicken soup adds a creamy texture to the sauce.
Tomatoes – Diced Rotel tomatoes add liquid.
Sour Cream – Sour cream to balance the salsa.
Salsa – One cup of thick mild, medium or hot salsa. Use your favorite brand.
Pepper – Finely diced jalapeno for a spicy flavor.
Seasonings – One packet of taco seasoning, plus garlic salt, ground cumin and lemon pepper.
Cheese – Colby jack cheese adds the melty texture and pulls everything together.
Chips – Crushed tortilla chips or Doritos form the base and the topping of the chicken casserole.
Toppings – Green onions, fresh cilantro, sour cream, salsa and diced roma tomatoes for serving.

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How to Make the BEST Mexican Chicken Casserole Recipe

Heat Oven and Prepare Baking Dish – Preheat oven to 350°F. Prepare a 13×9-inch baking pan with non-stick cooking spray.
Make the Filling Mixture – Add chicken, corn, black beans, soup, Rotel tomatoes, sour cream, and salsa to a large mixing bowl. Stir until fully combined.
Add Seasonings – Stir in taco seasoning, garlic salt, cumin and lemon pepper, plus cheese.
Assemble the Casserole – Sprinkle the bottom of the prepared baking dish with 2 cups tortilla chips. Spread chicken mixture evenly over the tortilla chip layer. Sprinkle with cheese and remaining tortilla chips.
Oven – Bake per the cook time in the recipe until the cheese has melted and the casserole is bubbly.
Serve – Top with green onions, cilantro, and diced tomato and serve with salsa and sour cream.

Equipment for Making Easy Mexican Chicken Casserole

13×9-inch casserole dish or pan.
Cheese grater to freshly shred the cheese.
Sharp knife and chopping board to prep the chicken and toppings.
Large bowl for mixing everything together.
Measuring cups and spoons.

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Recipe Variations, Tips and Substitutions

Rice – You could add 1 cup of cooked rice for a Mexican chicken rice casserole.
Seasonings – In place of a packet of taco seasoning you can make your own. See my recipe for Homemade Taco Seasoning here.
Peppers – You could add finely diced bell peppers or poblano pepper in place of jalapeño pepper.
Protein Substitutions – You can use shredded poached chicken breasts , chicken thighs, shredded beef, turkey or pulled pork in this casserole recipe.
Cheese – You could use cheddar cheese or pepper jack cheese for a little spice.
Soup – If you prefer, you can use cream of mushroom soup, cream of onion soup or cheddar cheese soup.
Sour Cream – You can use low fat sour cream in place of full fat sour cream. You could also use plain greek yogurt.
Beans – You could add pinto beans or light red kidney beans in place of black beans.
Cilantro – If you don’t care for cilantro you can omit it or replace it with fresh parsley.
Tortilla Chips – You can use any flavor of taco chips, fritos or Doritos.
How to Serve Mexican Chicken Casserole – After baking, the casserole can be topped with fresh ingredients like diced tomatoes, avocado, green onions, lettuce, olives, and extra sour cream for a refreshing contrast to the layers of crunchy chips, seasoned chicken and melty cheese. You may also opt to serve this with a side salad or Mexican rice to complete the meal.

Storage and Leftovers

Leftovers – Store leftover Mexican chicken casserole covered with aluminum foil or in an airtight container in the fridge for up to 3 days.
Reheating – Reheat in single servings in the microwave or in a preheated 350°F oven just until heated through.
Freezer Tips for Mexican Chicken Casserole – You can also freeze leftovers for up to 2 months. Remove it from the freezer and thaw it in the refrigerator overnight then reheat in a 350°F oven or air fryer to crisp the topping for an easy dinner.

More Easy Chicken Casserole Recipes to Make

Chicken and Rice Casserole is an oldie but goodie.
Crockpot Chicken and Dressing Casserole simmers in your slow cooker while you go about your day.
Chicken and Smoked Sausage Cassoulet is hearty and filling.
Mexican Salsa Chicken and Rice Casserole topped with your favorite taco fixings.
The family will flip for this Chicken Bacon Ranch Mac and Cheese.
Chicken Bacon Ranch Potato Casserole is a triple threat flavor combination.
Chicken Cordon Bleu Noodle Casserole is a family friendly weeknight meal.
Creamy Chicken Bacon Pasta is a stovetop casserole that comes together in minutes.
Slow Cooker Chicken Tater Tot Casserole from The Magical Slow Cooker.

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